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Search: L773:0197 4580 OR L773:1558 1497 > Winblad Bengt > University of Skövde > CSF/serum albumin r...

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CSF/serum albumin ratio in dementias : a cross-sectional study on 1861 patients

Skillbäck, Tobias (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Neurochem, Molndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden.,Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden / Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
Delsing, Louise (author)
Gothenburg University,Göteborgs universitet,University of Skövde,Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden,Bioinformatik, Bioinformatics,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Neurochem, Molndal, Sweden.;Univ Skovde, Sch Biosci, Syst Biol Res Ctr, Box 408, S-54128 Skovde, Sweden.
Synnergren, Jane (author)
University of Skövde,Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Bioinformatik, Bioinformatics,Univ Skovde, Sch Biosci, Syst Biol Res Ctr, Box 408, S-54128 Skovde, Sweden.
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Mattsson, Niklas (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden / Department of Neurology, Skåne University Hospital, Lund, Sweden,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden.;Skane Univ Hosp, Dept Neurol, Lund, Sweden.
Janelidze, Shorena (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden.,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Nägga, Katarina (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden.,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Kilander, Lena (author)
Uppsala universitet,Uppsala University,Geriatrik,Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden
Hicks, Ryan (author)
Discovery Sciences, IMED Biotech Unit, AstraZeneca, Mölndal, Sweden,AstraZeneca, IMED Biotech Unit, Discovery Sci, Molndal, Sweden.
Wimo, Anders (author)
Karolinska Institutet,Uppsala universitet,Uppsala University,Karolinska Institute,Centrum för klinisk forskning, Gävleborg,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Div Neurogeriatr, Huddinge, Sweden.,Centre for Research and Development, Uppsala University/County Council of Gävleborg, Gävle, Sweden / Division for Neurogeriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden
Winblad, Bengt (author)
Karolinska Institutet,Karolinska Institute,Division for Neurogeriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden / Department Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Div Neurogeriatr, Huddinge, Sweden.;Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden.
Hansson, Oskar (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden / Department of Neurology, Skåne University Hospital, Lund, Sweden,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden.;Skane Univ Hosp, Dept Neurol, Lund, Sweden.
Blennow, Kaj (author)
Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Neurochem, Molndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden.,Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden / Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
Eriksdotter, Maria (author)
Karolinska Institutet,Karolinska Institute,Department Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden / Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden,Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden.;Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Huddinge, Sweden.
Zetterberg, Henrik (author)
Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University College London,Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden / Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden / Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom / UK Dementia Research Institute at UCL, London, United Kingdom,Sahlgrenska Academy,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Neurochem, Molndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden.;UCL Inst Neurol, Dept Mol Neurosci, London, England.;UCL, UK Dementia Res Inst, London, England.
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 (creator_code:org_t)
Elsevier, 2017
2017
English.
In: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 59, s. 1-9
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362), Lewy body dementia (DLB, n = 50), frontotemporal dementia (FTD, n = 56), Parkinson's disease dementia (PDD, n = 23), other dementias (other, n = 48), and dementia not otherwise specified (NOS, n = 271). We compared CSF/serum albumin ratio to 2 healthy control groups (n = 292, n = 20), between dementia diagnoses, and tested biomarker associations. Patients in DLB, LAD, VaD, MIX, other, and NOS groups had higher CSF/serum albumin ratio than controls. CSF/serum albumin ratio correlated with CSF neurofilament light in LAD, MIX, VaD, and other groups but not with AD biomarkers. Our data show that BBB leakage is common in dementias. The lack of association between CSF/serum albumin ratio and AD biomarkers suggests that BBB dysfunction is not inherent to AD but might represent concomitant cerebrovascular pathology.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)

Keyword

Alzheimer's disease
Blood-brain barrier
CSF/serum albumin ratio
Dementia
Bioinformatik
Bioinformatics
INF502 Biomarkers
INF502 Biomarkörer
Alzheimer's disease
Blood-brain barrier
CSF/serum albumin ratio
Dementia

Publication and Content Type

ref (subject category)
art (subject category)

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